See Frame Essentials for a great Glucosamine, MSN, Boswellin product
The skeleton, made up of all the body’s bones, provides strength, stability, and a frame for muscles to work within to produce movement. Bones come together to form joints, most of which are in constant motion. The ends of bones are covered with cartilage, a smooth, tough, protective tissue that acts as a shock absorber and reduces friction. The skin acts as a protective barrier to the outside world. Skin also helps to regulate body temperature, senses painful and pleasant stimuli, and shields us from the sun’s harmful effects.
Today, we are seeing increasing incidences of problems with the musculoskeletal system. We can help ourselves maintain our "body frame" health through nutrition and supplements. One of the most powerful musculoskeletal supplements is glucosamine.
One way to think of cartilage is as a super sponge. It soaks up water (more accurately, synovial fluid) when a joint is at rest, and squeezes out the water when a joint moves. As the joint rests again, it again soaks up water. This spongelike effect of cartilage makes it a shock absorber, buffering our bones and body from the wear and tear of making thousands of movements per day. Cartilage is also slippery—five to eight times more slippery than ice. Thus, when two bones do meet, the cartilage at the ends of each bone allows them to slide off each other, adding to the buffering effect.
The cartilage matrix
As we have seen, water provides cartilage with buffering qualities, and also helps shape the "cartilage" sponge. It also feeds the cartilage. Cartilage contains no blood vessels, so the soaking up and squeezing out of water is what provides cartilage with nutrients.
Collagen also plays a role in giving cartilage its shape and resiliency, and it also absorbs shock. Think of collagen as super strong threads that create the framework to hold the third component of cartilage: proteoglycans.
Proteoglycans are large water-soluble molecules. They are woven in among the collagen threads, forming a kind of netting. This netting traps the water. Proteoglycans also act like magnets. The individual molecules push away from each other, again allowing for space and a buffering effect.
Finally, tiny factories called chondrocytes are located throughout this netting. They produce new collagen and proteoglycans, as well as enzymes that dispose of older, past-their-prime collagen and proteoglycans.
The role of Glucosamine
When things go wrong
When cartilage is damaged, the chondrocytes go into high gear, manufacturing more proteoglycans and collagen. Unfortunately, these replacements may be of inferior quality, or be overproduced, resulting in bumpy joint surfaces. Chondrocytes also produce more of the enyzmes that "eat away" old matter. These enzymes may begin attacking the new, inferior cartilage, with an end result of diminished cartilage, not more cartilage. This also may result in fewer proteoglycans, which means the cartilage cannot hold water well. The cartilage can then dry out and wear out more quickly.
The result is that we begin to feel our bones rubbing together during movement. We experience pain and stiffness.
What to do
The first studies were performed in the 1960s, using injectable forms of glucosamine sulfate. When glucosamine sulfate became available in pill form, research switched to this.
Up to the present, most glucosamine studies have been performed outside of North America. In all of these studies, glucosamine sulfate proves to maintain joint health.
It should be noted that although there are positive results in all of these studies, not all participants experience them. Thus, although glucosamine works for many people, it does not necessarily work for all people.
Frame Essentials ™ contains two types of glucosamine—glucosamine sulfate and glucosamine hydrochloride (HCL)—with methylsulfonylmethane (MSM) and boswellin extract. This unique formula provides you with an all-around product to maintain healthy joints and promote ease of movement.
mitigate, or prevent a disease or illness. Results may vary per person"
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